Synthesis of 2-(1-Oxo-2,3-Dihydro-1H-Pyrrolizin-2-yl)-2-(Aryl)Acetonitrile Derivatives Via Michael Addition of Trimethylsilyl Cyanide
نویسندگان
چکیده
منابع مشابه
(E)-2-(2-Furylmethylidene)-2,3-dihydro-1H-pyrrolizin-1-one
The title compound, C(12)H(9)NO(2), was prepared by an Aldol reaction of furfuraldehyde with 2,3-dihydro-1H-pyrrolizin-1-one. The mol-ecule is almost planar, with an r.m.s. deviation of 0.045 Å, excluding the methyl-ene H atoms. In the crystal structure, mol-ecules are linked via weak inter-molecular C-H⋯O hydrogen bonding and aromatic π-π stacking [centroid-centroid distance = 3.6151 (9) Å].
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The condensation of 2-carb-oxy-benzaldehyde with 1,2-phenyl-enediamine unexpectedly yielded the title compound, C(22)H(14)N(2)O(4)·CH(4)O. The benzimidazole ring system is almost perpendicular to the phthalazine ring system, making a dihedral angle of 88.4 (5)°. Inter-molecular O-H⋯N and O-H⋯O hydrogen-bonding inter-actions stabilize the crystal structure.
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The seven-membered ring in the title compound, C(19)H(18)N(2)O(3), adopts a boat conformation with the two phenyl-ene C atoms representing the stern and the methyl-ene C atom the prow. The dihedral angle between the best plane through the seven-membered ring (r.m.s deviation = 0.343 Å) and the phenyl substituent is 31.9 (1)°. The dihedral angle between this best plane and the best plane through...
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ژورنال
عنوان ژورنال: Journal of Chemical Research
سال: 2018
ISSN: 1747-5198,2047-6507
DOI: 10.3184/174751918x15357145868004